Comparison of the Haemodynamic Parameters of Venous and Arterial Coronary Artery Bypass Conduits.
نویسندگان
چکیده
Dear Editor, Coronary artery bypass grafting (CABG) is an established revascularisation treatment for patients with coronary artery disease (CAD). However, the graft patency rate varies significantly among different bypass graft conduits. Ten years after CABG, more than 90% of the left internal mammary artery (LIMA) grafts are patent1 but the patency rate of saphenous vein grafts (SVGs) ranges from 40% to 50%.2 Radial artery (RA) grafts have better long-term patency than SVGs.3 The pathogenetic mechanisms responsible for the early development of thrombosis, intimal hyperplasia (IH) and atherosclerosis in grafts remain elusive. Physicians generally believe that haemodynamic forces on blood vessels, especially wall shear stress (WSS), play an important role in initiating the process of atherosclerosis.4,5 Signalling pathways have been proposed to mediate the mechanochemical transduction in endothelial cells in response to disturbed flow and WSS.6 Recent developments in transit time flowmetry (TTFM) not only provide intraoperative mean graft flow (MGF), pulsatility index (PI) and diastolic filling (DF) measurements, but also provide a foundation for estimating WSS from the MGF and graft diameter. We hypothesise that WSS may play a role in graft patency and the purpose of this study was to examine the relationship between graft conduit types and haemodynamic parameters, such as MGF, PI, DF and WSS.
منابع مشابه
Comparison of the right internal thoracic artery and radial artery as a second arterial conduit in ‘Y’ composite fashion in patients undergoing coronary artery bypass grafting using total arterial revascularization
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ورودعنوان ژورنال:
- Annals of the Academy of Medicine, Singapore
دوره 45 8 شماره
صفحات -
تاریخ انتشار 2016